CDK
CDK (Cyclin-dependent kinases) is a group of serine/threonine kinases. It is activated by binding to cyclin and participates in the regulation of cell cycle.
Most of the known cyclin-CDK complexes regulate the progression through the cell cycle. Animal cells contain at least nine CDKs, four of which, CDK1, 2, 3, and 4, are directly involved in cell cycle regulation. In mammalian cells, CDK1, with its partners cyclin A2 and B1, alone can drive the cell cycle. Another one, CDK7, is involved indirectly as the CDK-activating kinase. A cyclin-dependent kinase inhibitor (CKI) is a protein that interacts with a cyclin-CDK complex to block kinase activity, usually during G1 or in response to signals from the environment or from damaged DNA.
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Ryuvidine是SETD8 抑制剂， 也是CDK4 抑制剂。
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PHA 767491 hydrochloride是MK2 抑制剂， 也是抑制 cdc7/cdk9。
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Olomoucine是Cyclin-dependent 激酶抑制剂。
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NU 2058是Cdk1，cdk2 抑制剂。
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NU 6140是Cyclin-dependent kinase 2 (cdk2) 抑制剂。
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